Of course, a renewed Scrubs could benefit from its new lease on life by focusing on the inexperienced interns introduced this season, which would return the show back to the roots of its comedy core: inexperienced doctors learning what medicine is all about. While the cast exit could make Scrubs: The Next Generation seem like a comedy on the best diet pills, it could also move on to produce a second generation of stars.

The real question is whether the show can hold its core audience without Braff and company around to anchor it.